CRISPR Functional Genomics Services

CD Genomics offers various solutions, from genome-wide association studies on tens of thousands of samples to single SNP interrogations of several hundred individuals. Our experts and technicians are knowledgeable and have years of experience providing CRISPR Functional Genomics Services.

Name of the Instrument/Technicial Service

CRISPR Functional Genomics Services

Our Services

Cas-expressing cell line generation (Cas9, nCas9, dCas9, dCas9 fusions, Cas12a, Cas13d)
CRISPR-ko, CRISPR-inhibition, CRISPR-activation screens
Multiplexed Cas12a screens
Base-editor screens
RNA targeting screens with Cas13d
Small pooled screens with single cell transcriptomic readout
Experienced support for screen design
Custom-made lentiviral guide libraries produced and provided
Library transduction performed
NGS libraries prepared
NGS at NGI Stockholm included in the pipeline
Data analysis: hit list generated

Summary

Our service portfolio includes CRISPR gene perturbation followed by single-cell RNASeq. We are developing base-editing approaches for targeted mutagenesis screens to characterize protein-protein or protein-drug interactions.

Applications

Determine essential genes in specific cell types
Screen for drug resistance/sensitivity genes
Find novel genes/pathways involved in any cellular process
Map novel genes/pathways regulating a reporter gene

CD Genomics has already updated its technology platforms to mainstream NGS, long-read sequencing, and microarray instruments. We continue to strive to offer the same reliable services to pharmaceutical and biotechnology companies, as well as academia and government agencies, for all your sequencing or array needs. If you are interested, please contact us directly for assistance.

Online Inquiry

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